What question did this study set out to answer?

The study aims to investigate how different dietary fats affect tumor growth and biology in a colorectal cancer mouse model.

April 5, 2026

Abstract 930: Mediterranean versus Western diet - preventative and interventional effects of dietary lipids on colorectal tumor growth and biology.

Key Points

The study aims to investigate how different dietary fats affect tumor growth and biology in a colorectal cancer mouse model.
Mice assigned to different high-fat diets (lard vs. olive oil)
Measurement of body composition and glucose tolerance
Induction of tumorigenesis via tamoxifen after diet exposure
Analysis of tumor growth through endoscopic measurements over one year
In vitro studies on fatty acid oxidation and lipogenesis pathways
Both high-fat diets resulted in metabolic dysfunction compared to a low-fat diet
Mice on high-fat diets showed increased body weight, fat mass, and glucose intolerance
Lipid components differed significantly between diet types, impacting tumor metabolism
Preliminary evidence indicates similar cholesterol levels in olive oil and low-fat diet groups, but lower than high-fat diet group

Abstract

Abstract The purpose of this study was to examine the preventative and interventional effects of different fat sources (lard verses olive oil) and their respective lipid components in a Western-style high-fat diet and Mediterranean-style high-fat diet on tumor biology in vivo in a Cre-lox mouse model called iKAP (inducible Kras, Apc, p53) of colorectal cancer (Boutin et al, Genes thus, differences in tumor metabolism and growth remain a pertinent question. Citation Format: Cara C. Wallingford, Anindita Mahanty, Revan Hammontree, Alexa Magstadt, Jennifer Davis. Mediterranean versus Western diet - preventative and interventional effects of dietary lipids on colorectal tumor growth and biology abstract. In: Proceedings of the American Association for Cancer Research Annual Meeting 2026; Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 930.

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