June 8, 2015Open Access

Atrial fibrillation driven by micro-anatomic intramural re-entry revealed by simultaneous sub-epicardial and sub-endocardial optical mapping in explanted human hearts

Structured PICO

Population

Explanted diseased human right atria (ex vivo model)

Intervention

Simultaneous sub-epicardial and sub-endocardial optical mapping with pacing

Outcome

Differences between endocardial and epicardial activation during pacing and sustained atrial fibrillationsurrogate

Simultaneous optical mapping of explanted human hearts reveals that sustained atrial fibrillation is driven by intramural re-entry anchored to fibrosis-insulated atrial bundles.

Abstract

Integrated 3D structural-functional mapping of diseased human right atria ex vivo revealed that the complex atrial microstructure caused significant differences between Endo vs. Epi activation during pacing and sustained AF driven by intramural re-entry anchored to fibrosis-insulated atrial bundles.

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Cite This Study

Hansen et al. (Mon,) studied this question.

synapsesocial.com/papers/69d56df475589c71d767d21d https://doi.org/https://doi.org/10.1093/eurheartj/ehv233

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