Atrial amyloidosis is highly prevalent in patients with long-standing AF and rheumatic heart disease, suggesting it is an additional histological feature in structural atrial remodeling.
Patients with long-standing AF and rheumatic heart disease have a very high prevalence of atrial amyloidosis. Amyloid deposition is more frequent in left than in right atrial appendage and correlates with AF duration and female gender. Amyloid deposition could constitute an additional histological feature in the structural remodeling of atria during long-standing AF, at least in rheumatic valve disease. Persistence of AF might play a pivotal role in promoting amyloid deposition.
Ornella Leone (Thu,) studied this question.