Purpose: Weight reduction (WR) can reduce liver volume, affecting the graft-to-recipient weight ratio (GRWR).This study aimed to evaluate the decrease in liver volume after WR and analyze risk factors affecting liver volume reduction in potential liver donors with steatosis.Methods: We retrospectively reviewed data of 147 potential liver donors with steatosis who participated in a WR program prior to liver transplantation between January 2016 and December 2021.Total liver volume (TLV) was measured using CT and MRI.Risk factors for large liver volume reduction (10%) were analyzed using multivariate logistic regression.Results: Ninety-seven donors (66.0%) underwent donor hepatectomy after WR.Liver volumes showed a statistically significant decrease (from 1,399.6 315.4 mL to 1,283.6 271.2 mL, P < 0.05).Thirty-eight donors (42.7%) showed large liver volume reduction.There was a more significant reduction in weight, AST, and ALT in the large liver volume reduction group than in the small liver volume reduction group (all P < 0.05).WR percentage and ALT abnormalities were independent risk factors for large liver volume reduction (odds ratio, 1.184 95% confidence interval, 1.054-1.329and odds ratio, 5.502 95% confidence interval, 1.660-18.229,respectively; all P < 0.05).Conclusion: Potential liver donors with 7% or more WR or ALT abnormality require liver volume/GRWR remeasurement after WR to ensure adequate graft size and prevent small-for-size syndrome.
Hong et al. (Thu,) studied this question.