Increasing incidence and changing distribution of primary cancers in therapy‐related acute myeloid leukemia: A population‐based study in Osaka, Japan, 1990–2020

Key Points

• This research aims to analyze the trends in the incidence and distribution of primary cancers leading to therapy-related acute myeloid leukemia (tAML) over a specified period.
• Analyzed population-based data from Osaka, Japan from 1990 to 2020
• Assessed annual incidence rates of tAML
• Evaluated changes in the distribution of primary cancers associated with tAML
• Observed a gradual increase in annual incidence rates of tAML
• Noted changes in the distribution of types of primary cancers leading to tAML
• Indicated a growing concern related to tAML as a complication of prior cancer therapies