Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma | Synapse
April 8, 2026Open Access
Hypogonadotropic Hypogonadism Before and After Transsphenoidal Surgery for Non‐Functioning Pituitary Adenoma
Key Points
The study aims to evaluate the prevalence of hypogonadotropic hypogonadism in patients with non-functioning pituitary adenomas and the effects of transsphenoidal surgery on recovery of the HPG axis.
Assessment of hypogonadotropic hypogonadism in patients pre- and post-transsphenoidal surgery
Comparison of recovery rates between genders
Evaluation of quality of life post-surgery
Higher postoperative recovery rate of the HPG axis noted in women compared to men
Improved quality of life linked to successful hormonal recovery post-surgery
Abstract
HH is frequent in men and women with NFPA planned for TSS. Postoperative HPG axis recovery rate is higher in women and is associated with improved QoL.