How does physiological aging affect baroreflex buffering in healthy men?
Physiological aging in healthy men reduces baroreflex buffering, which may explain altered responsiveness to vasoactive drugs in older patients.
Physiological aging in men is associated with a marked reduction in baroreflex buffering. The decrease in baroreflex buffering with aging is related to increases in basal sympathetic nerve activity and reductions in systemic alpha1-adrenergic vascular responsiveness. These findings are helpful for interpreting changes in baroreflex buffering in older patients with cardiovascular disease, as well as changes in responsiveness to vasoactive drugs with aging.
Jones et al. (Tue,) studied this question.