The ratio of NT-proBNP to BNP in HFrEF is significantly influenced by atrial fibrillation, age, and renal function, which must be accounted for when comparing natriuretic peptide concentrations.
The ratio of NT-proBNP to BNP in heart failure and reduced ejection fraction appears to be greater than generally appreciated, differs between patients with and without atrial fibrillation, and increases substantially with increasing age and decreasing renal function. These findings are important for comparison of natriuretic peptide concentrations in heart failure and reduced ejection fraction.
Rørth et al. (Sat,) studied this question.
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