Do plasma p-tau217, p-tau181, and NfL predict long-term cognitive decline and incident dementia in older community-dwelling individuals?
Plasma p-tau217, p-tau181, and NfL are promising early predictive markers for cognitive decline and incident dementia in older adults.
Plasma p-tau217 may be an early predictive marker of AD and Aβ pathology in older community-dwelling individuals.Highlights: Plasma p-tau217, p-tau181, and NfL were positively associated with long-term cognitive decline and risk of incident dementia.Plasma p-tau217 showed a better performance distinguishing Aβ+ individuals from Aβ- individuals at follow-ups.Plasma NfL may be a suitable predictor of general cognitive decline in older community-dwelling individuals.
Xiao et al. (Sun,) studied this question.