Can peripheral blood PIP serve as a useful marker of myocardial fibrosis in patients with heart failure of hypertensive origin?
Peripheral blood PIP may serve as a useful non-invasive biomarker for detecting myocardial fibrosis in patients with hypertensive heart disease and heart failure.
These findings suggest that an excess of cardiac collagen type I synthesis and deposition may be involved in the enhancement of myocardial fibrosis that accompanies the development of HF in HHD. In addition, our data show that the heart secretes PIP via the coronary sinus into the peripheral circulation in patients with HHD. Thus, PIP determined in peripheral blood can be a useful marker of myocardial fibrosis in these patients.
Querejeta et al. (Tue,) studied this question.