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In this work, silver-entecavir nanoparticles (Ag-ETR) were successfully synthesized using the green synthetic procedure and caped by entecavir that worked as a reducing agent, as it has amino and hydroxy functional groups. Synthesis of NPs was confirmed by UVS spectrophotometry and thin-layer chromatography while surface functionalization was studied using Fourier transform infrared spectrometer and scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDS). Morphological studies of synthesized NPs were performed using the scanning electron microscopy, atomic force microscopy, and zetasizer. Structure of self-assembly Ag-ETR nano-clusters was proposed by UV–vis spectroscopy, FT-IR, H-NMR, X-ray diffraction, and SEM-EDS. The stoichiometry of Ag-ETR NPs was found to be 8:2 (ETR and Ag) and 120–188 nm in size, while having a surface charge –13.7 mv. Decomposition kinetics of Ag-ETR NPs was determined by Horowitz-Metzger method and allied kinetic parameter including Gibb’s free energy (ΔG), change in entropy (ΔS) and heat of enthalpy (ΔH) were determined. ETR conjugated Ag NPs exhibited significantly increased stability and aqueous solubility. Ag-ETR NPs could be a promising agent to have better synergistic effect, are expectedly reduce drug resistance which is corroborated to different cellular uptake mechanisms and may increase bioavailability as NPs had high water solubility.
Shoaib et al. (Sun,) studied this question.