What is the genetic architecture of Spontaneous Coronary Artery Dissection compared to controls?
SCAD has a complex genetic architecture with overlap with connective tissue diseases and a higher burden of common variants compared to controls.
SCAD shares some genetic overlap with CTD, even in the absence of any major CTD phenotype. Consistent with a complex genetic architecture, SCAD patients also have a higher burden of common variants than controls.
Tarr et al. (Wed,) studied this question.