Partial tandem duplication of KMT2A (MLL) may predict a subset of myelodysplastic syndrome with unique characteristics and poor outcome

Partial tandem duplication (PTD) of the KMT2A (MLL) gene is detected in approximately 5-10% of cases of acute myeloid leukemia (AML)11–52 and within cases showing normal karyotype, confers a worse prognosis.23,64,75 In these patients, the duplications are variable in size and