What question did this study set out to answer?

The aim is to develop hydrogels that can respond to MMPs for better healing of infected wounds.

April 10, 2026Journal of Materials Chemistry B0 citations

MMP-Responsive Bioactive Glass-Incorporated Hydrogels with Enhanced Antibacterial and Angiogenic Performance for Infected Wound Healing

WSWenyi ShaoHunan University MXMin XingShanghai Stomatological Hospital LZLi ZhaoQiqihar University

Key Points

The aim is to develop hydrogels that can respond to MMPs for better healing of infected wounds.
Created MMP-responsive hydrogels incorporated with bioactive glass
Assessed antibacterial performance through bacterial cultures
Evaluated angiogenic effects using cellular assays
Hydrogels showed significant antibacterial activity against common wound pathogens
Enhanced angiogenesis was observed in treated wounds compared to controls
Demonstrated improved healing metrics in MMP-rich environments

Abstract

Chronic wounds are difficult to heal due to complex pathological features such as bacterial infection, abnormal expression of matrix metalloproteinases (MMPs), and impaired angiogenesis, posing a serious threat to public...

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