Glial pathology networks reveal early olfactory vulnerability in post mortem human Alzheimer's disease

Key Points

• The aim is to explore the architecture of glial pathology in the human olfactory system in relation to Alzheimer's disease.
• Analyzed post mortem human brain samples from Alzheimer's disease patients.
• Examined spatial patterns of glial pathology in the olfactory system.
• Compared findings to other brain regions to assess regional vulnerabilities.
• Identified diverse and spatially uneven glial pathology architectures in the olfactory system.
• Highlight that the olfactory system shows early signs of vulnerability in Alzheimer's disease.
• Demonstrated that the olfactory system may be affected before other brain regions.