What question did this study set out to answer?

Explore the enhanced recognition of G-quadruplex DNA structures important for gene regulation and cancer.

April 10, 2026

Enhanced biophysical, electrochemical and computational recognition of cancer-relevant G-quadruplex DNA by ferrocenyl curcumin Schiff base motifs

PSPadma SharmaNational Institute of Technology Patna NJNiki S. JhaNational Institute of Technology Patna ARAnupama RaiNational Institute of Technology Patna

Key Points

Explore the enhanced recognition of G-quadruplex DNA structures important for gene regulation and cancer.
Investigated biophysical characteristics of G-quadruplex DNA.
Utilized electrochemical techniques for detection.
Applied computational analyses for interaction modeling.
Improved binding affinity of ferrocenyl curcumin to G-quadruplex DNA.
Significant electrochemical signal changes observed with target DNA.
Computational models confirm interaction stability and specificity.

Abstract

G-quadruplex DNA structures located in promoter and telomeric regions play critical roles in gene regulation and cancer progression, making them attractive targets for small-molecule intervention.

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