A systematic review on clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs) with high TDM scores

Key Result

Clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors with high therapeutic drug monitoring scores are being evaluated in a registered systematic review.

Key Points

• The review aims to evaluate the clinical pharmacokinetics and pharmacodynamics of antiangiogenic tyrosine kinase inhibitors (TKIs).
• Conducted a systematic literature review
• Analyzed pharmacokinetic and pharmacodynamic properties
• Evaluated therapeutic drug monitoring (TDM) scores
• Identified key pharmacokinetic parameters of various TKIs
• Highlighted implications of TDM scores on drug efficacy
• Discussed the variability in drug response among different populations