Novel CD8 + Regulatory T Cells Attenuate Eosinophilic Infiltration in a Murine Allergic Asthma Model

Key Points

• The aim is to investigate the role of CD8+ regulatory T cells in modulating eosinophilic infiltration in an allergic asthma model.
• Utilized a murine model induced by OVA for asthma.
• Administered CD8+ T regulatory cells derived from B cells.
• Measured levels of Th2 cytokines (IL-4, IL-5, IL-13) and eosinophilic infiltration in BALF.
• CD8+ Tregs significantly suppressed Th2 cytokine proliferation.
• Eosinophilic infiltration in bronchoalveolar lavage fluid (BALF) was downregulated by CD8+ Tregs.