What question did this study set out to answer?

This study aims to evaluate the association of biological age with survival outcomes among older patients with early-stage NSCLC after radiation therapy.

April 10, 2026Open Access

Multimodal Assessment of Biological Age Following Radiation Therapy Among Patients With Early-Stage NSCLC

Key Points

This study aims to evaluate the association of biological age with survival outcomes among older patients with early-stage NSCLC after radiation therapy.
Conducted a cohort study involving older patients with early-stage NSCLC receiving stereotactic body radiation therapy (SBRT).
Assessed biological age using facial analysis and lung age through spirometry.
Analyzed the relationship between biological age and survival outcomes.
Face age was identified as an independent biomarker linked to survival and early mortality.
Biological and lung age measures helped in individualized risk stratification.
Noninvasive assessment methods were found to be complementary and beneficial for treatment planning.

Abstract

In this cohort study of older patients with early-stage NSCLC receiving SBRT, face age was an independent biomarker associated with survival and early mortality and complemented lung age. These noninvasive measures, obtainable from routine photographs and spirometry, may aid individualized risk stratification and treatment planning.

Multimodal Assessment of Biological Age Following Radiation Therapy Among Patients With Early-Stage NSCLC

Key Points

Abstract

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