What question did this study set out to answer?

The research aimed to identify clinical factors that contribute to improvement in disorganization among individuals at clinical high risk for psychosis over two years.

April 10, 2026Open Access

Clinical Factors Influencing Improvement in Disorganization in Clinical High‐Risk for Psychosis: Preliminary Findings From a 2‐Year Follow‐Up

Key Points

The research aimed to identify clinical factors that contribute to improvement in disorganization among individuals at clinical high risk for psychosis over two years.
Studied 180 individuals at clinical high risk for psychosis (CHR-P)
Utilized assessments including GAF and PANSS
Conducted a longitudinal follow-up over two years
61.7% of participants showed a decrease in disorganization
Improvement was associated with a shorter duration of untreated illness
Greater improvement in negative symptoms correlated with better outcomes
Prescription of antipsychotics was linked to improved disorganization

Abstract

Disorganization is under-treated in early psychosis. We aimed at exploring clinical factors potentially improving disorganization in individuals at Clinical High Risk for Psychosis (CHR-P) across 2 years of follow-up. About 180 participants completed the GAF and the PANSS. Longitudinally, 111 (61.7%) individuals had a decrease in disorganization. Significant associations of this improvement were with shorter duration of untreated illness, higher improvement in negative symptoms, and antipsychotic prescription.

Clinical Factors Influencing Improvement in Disorganization in Clinical High‐Risk for Psychosis: Preliminary Findings From a 2‐Year Follow‐Up

Key Points

Abstract

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