Apus bamboo shoot extract formulation accelerates the healing of myasis-infected wounds in Wistar rats

Myiasis, a type of tissue infection caused by fly larvae, can lead to significant tissue damage and delayed wound healing. Conventional treatment with antibiotics and larvicides often poses risks of resistance and side effects. This study aimed to evaluate the effectiveness of apus bamboo shoot (Gigantochloa apus) extract in accelerating wound healing caused by myiasis infection in Wistar rats. Twenty-five Wistar rats were divided into five groups: a negative control (CN) group, a positive control (CP) with ivermectin, and three groups treated with 1%, 3%, and 5% apus bamboo shoot extract. Compared with the positive control (ivermectin), 5% apus bamboo shoot extract (P3) had the greatest effect on reducing wound length on days 7 and 11. Histopathological analysis revealed improved granulation tissue formation, increased fibroblast number, and reduced inflammation. Compared to the negative control group, the inflammatory cell counts were lower in all treatment groups, with significant decreases observed in groups treated with %, and 5% apus bamboo shoot extract. The apus bamboo shoot extract has potential as an effective natural treatment for myiasis wound healing, with bioactive compounds contributing to its anti-inflammatory, antibacterial, and larvicidal properties. However, further clinical studies are required to confirm its applicability.