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Growing concern about acute renal failure as the result of contrast agents prompted an investigation into the renal effects of intravenous contrast materials in euvolemic and dehydrated dogs. Bolus injection of hypertonic agents induced marked reductions in filtration fraction and glomerular filtration rate in both groups of animals; however, these changes were transient, returning to near-base-line values within 30 minutes after injection. The most striking differences between euvolemic and dehydrated animals appeared to be related to prerenal factors such as hypovolemia and contrast-induced hypotension.
Katzberg et al. (Sun,) studied this question.