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The paper introduced the principle of nitration reaction and flow chemistry, beginning with background information and the reaction mechanism of nitration. Then the correlation between nitration and flow chemistry is further explored by comparing the nitration reaction in conventional batch mode and under continuous flow. As the dangerous corrosive acids and strong exotherms make the reaction especially difficult to increase production scale, flow chemistry is utilized and proved to be a better alternative to the conventional production method to perform nitration. Using flow chemistry to scale up the exothermic and hazardous nitration reactions offer advantages including better yield, higher production rate, enhanced safety, etc.
Lu et al. (Fri,) studied this question.