Fresh porcine aortic valve leaflets demonstrate marked mechanical anisotropy, with circumferential strength driven by aligned collagen bundles, informing the biomechanics of bioprosthetic valves.
The tensile viscoelastic properties of radial and circumferential strips of fresh porcine aortic valve leaflets have been examined and compared with the fiber architecture of the leaflets as seen in the scanning electron microscope. The leaflet material showed nonlinear viscoelasticity, largely independent of strain rate, and dependent on the degree of preconditioning by cyclic loading. Preconditioning to a stable stress-strain response could only be accomplished on 1-cm-long strips above a minimum width of 4 mm (circumferential) and 6 mm (radial). Preconditioning yielded a more elastic and extensible material with reduced hysteresis. The leaflets were markedly anisotropic. Circumferential strips were up to 8 times stronger and stiffer than radial strips, and displayed greater stress relaxation and less creep. The circumferential mechanical properties were due to well-aligned circumferential collagen bundles reinforcing the composite structure, while radial properties were due to a more random collagenous support throughout the leaflet. Despite the presence of a septal shelf on the right coronary leaflet, no mechanical differences could be discerned between leaflets.
Lee et al. (Sun,) studied this question.
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