Sharpless Asymmetric Aminohydroxylation: Scope, Limitations, and Use in Synthesis

As a valuable methodology for organic synthesis, asymmetric aminohydroxylation (AA)-the catalytic and asymmetric conversion of alkenes into enantiomerically enriched N-protected amino alcohols-has become established in a remarkably short period of time. Examples of the types of products that can be synthesized easily on a reasonably large scale and in enantiomerically pure form are shown in the picture.