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The CAT model appears to be more robust than WAG against LBA artefacts, essentially because it correctly anticipates the high probability of convergences and reversions implied by the small effective size of the amino-acid alphabet at each site of the alignment. More generally, our results provide strong evidence that site-specificities in the substitution process need be accounted for in order to obtain more reliable phylogenetic trees.
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Lartillot et al. (Mon,) studied this question.
synapsesocial.com/papers/69dad8cd0d8d6ef495a3c5ac — DOI: https://doi.org/10.1186/1471-2148-7-s1-s4
Nicolas Lartillot
Université Claude Bernard Lyon 1
Henner Brinkmann
Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures
Hervé Philippe
Centre National de la Recherche Scientifique
BMC Evolutionary Biology
Centre National de la Recherche Scientifique
Université de Montréal
Université de Montpellier
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