BGP ‐15 Mitigates Oxidative Stress and Mitochondrial Dysfunction in In Vitro Matured Oocytes From Type 1 Diabetic Mice

Diabetes is highly associated with the decline of oocyte quality, which could further result in damage to embryo development and pregnancy outcomes. However, effective strategies for improving oocyte quality of patients with diabetes have not been fully determined. In this study, we report that supplementing BGP-15 in in vitro maturation (IVM) medium could significantly improve the maturation rate of oocytes from diabetic mice. BGP-15 supplementation could also alleviate oxidative stress and mitochondrial damage of in vitro matured oocytes from diabetic mice. Transcriptome analysis indicates that the effect of diabetes on oocytes is mainly related to dysregulation in metabolism pathways and mitochondrial-related pathways. The beneficial effect of BGP-15 on diabetic oocytes is mediated by reducing DNA damage to oocytes and increasing mitochondrial fatty acid β-oxidation. Collectively, our findings demonstrate that BGP-15 supplementation can protect oocytes from maternal diabetes-related damage and provide a potential strategy to improve reproductive outcomes of women with diabetes.