Protective effect of nebivolol on bleomycin-induced lung fibrosis via suppressing TLR4/IL-1β/MMP-2 and TGF-β/HSP47 signaling pathways in rats

Key Points

• The aim is to evaluate the protective effects of nebivolol on bleomycin-induced lung fibrosis and the underlying mechanisms.
• Administered nebivolol treatment to rats exposed to bleomycin.
• Assessed lung fibrosis using histological and biochemical analyses.
• Evaluated signaling pathways involving TLR4, IL-1β, MMP-2, TGF-β, and HSP47.
• Nebivolol significantly reduced the severity of lung fibrosis in treated rats.
• Suppressed the activation of TLR4/IL-1β/MMP-2 signaling pathways.
• Inhibited TGF-β and HSP47 signaling, indicating reduced fibrosis.