January 27, 2015Open Access

Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

JYJun J. YangSt. Jude Children's Research Hospital WLWendy LandierUniversity of Alabama at Birmingham WYWenjian YangSt. Jude Children's Research Hospital

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Abstract

We describe a germline variant in NUDT15 strongly associated with MP intolerance in childhood ALL, which may have implications for treatment individualization in this disease.

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Yang et al. (Tue,) studied this question.

synapsesocial.com/papers/69dcc52e89c4deb67d359ba4 https://doi.org/https://doi.org/10.1200/jco.2014.59.4671

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