How does right ventricular-pulmonary artery coupling and RV reserve respond to exercise in patients with HFpEF?
Impaired right ventricular reserve during exercise contributes to the pathophysiology of HFpEF, highlighting the importance of biventricular dysfunction.
In addition to limited LV reserve, patients with HFpEF display impaired RV reserve during exercise that is associated with high filling pressures and inadequate CO responses. These findings highlight the importance of biventricular dysfunction in HFpEF and suggest that novel therapies targeting myocardial reserve in both the left and right heart may be effective to improve clinical status.
Borlaug et al. (Sun,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: