A multimodal surveillance strategy integrating left ventricular global longitudinal strain, left atrial reservoir strain, and high-sensitivity troponin I demonstrated excellent discrimination for early anthracycline-induced cardiotoxicity (AUC 0.979).
Cohort (n=50)
No
Does a multimodal surveillance strategy integrating LVGLS, LASr, and hs-TnI predict early anthracycline-induced cardiotoxicity in female breast cancer patients?
A multimodal approach combining LVGLS, LASr, and hs-TnI effectively predicts early anthracycline-induced cardiotoxicity in breast cancer patients, with hs-TnI demonstrating the highest discriminative ability.
Effect estimate: AUC 0.979 (95% CI 0.954-1.000)
p-value: p=0.003
Abstract Background Anthracycline-based chemotherapy is highly effective in breast cancer treatment but is limited by dose-dependent cardiotoxicity. Early identification of subclinical myocardial injury is crucial to prevent progression to irreversible dysfunction. Objectives To evaluate whether a multimodal surveillance strategy integrating left ventricular global longitudinal strain (LVGLS), left atrial reservoir strain (LASr), and high-sensitivity troponin I (hs-TnI) can predict early anthracycline-induced cardiotoxicity. Methods This retrospective cohort study included 50 female breast cancer patients (mean age 49.3 ± 8.5 years) treated between January 2022 and December 2024. Echocardiography and biomarkers were assessed at baseline and 1 month after chemotherapy. Cardiotoxicity was defined as a > 10% reduction in LVEF to < 53%. Results Cardiotoxicity occurred in 15 patients (30%). LVGLS, LASr, and hs-TnI significantly changed (all P < 0.001). Independent predictors were LVGLS (aOR 1.33), LASr (aOR 0.77), and hs-TnI (aOR 1.07). hs-TnI showed the highest discriminative ability (AUC 0.940). Conclusions LVGLS, LASr, and hs-TnI provide complementary information for early detection of cardiotoxicity. Graphical Abstract
Kaya et al. (Sun,) conducted a cohort in Breast cancer treated with anthracycline-based chemotherapy (n=50). Multimodal surveillance strategy (LVGLS, LASr, and hs-TnI) vs. Single-parameter assessment (LVGLS alone) was evaluated on Early anthracycline-induced cardiotoxicity (> 10% reduction in LVEF to < 53% at 1 month) (AUC 0.979, 95% CI 0.954-1.000, p=0.003). A multimodal surveillance strategy integrating left ventricular global longitudinal strain, left atrial reservoir strain, and high-sensitivity troponin I demonstrated excellent discrimination for early anthracycline-induced cardiotoxicity (AUC 0.979).