Early lumbar drainage plus intrathecal urokinase in severe aneurysmal subarachnoid hemorrhage: the LD-ITUK randomized controlled trial protocol

Key Points

• To assess the effectiveness of early lumbar drainage combined with intrathecal urokinase in patients with severe aneurysmal subarachnoid hemorrhage.
• Conducting a randomized controlled trial with a control group and an intervention group.
• Participants will undergo lumbar drainage and treatment with intrathecal urokinase.
• Outcome measures will include neurological status and complications as assessed post-treatment.
• Expected to reveal differences in neurological outcomes between the two treatment groups.
• Aim to establish whether the combination treatment reduces complications from aneurysmal subarachnoid hemorrhage.