Metabolic Score for Visceral Fat and Gallstone Disease Risk: A Multicenter Cohort Study and Mediation Analysis of Inflammatory Biomarkers

Key Result

An increased Metabolic Score for Visceral Fat (METS-VF) is associated with a higher risk of gallstone disease.

Key Points

• This study explores how the metabolic score for visceral fat relates to the risk of gallstone disease (GSD) and the role of inflammatory biomarkers.
• Conducted a multicenter cohort study to assess the METS-VF (Metabolic Score for Visceral Fat) levels.
• Analyzed the association between METS-VF and gallstone disease risk.
• Performed mediation analysis focusing on inflammatory biomarkers.
• Found that higher METS-VF levels correlate with increased gallstone disease risk.
• Identified specific inflammatory biomarkers that mediate this relationship.