This study established porcine gastrointestinal fluids as biorelevant alternative to synthetic simulations and human-derived fluids, which involve greater ethical complexity for probiotic viability assessment. These findings highlight the importance of developing strategies to enhance probiotic resilience during gastric transit, the main barrier to oral survival, ensuring their functional delivery to the intestinal tract, where their benefits can be maximized.
Fredua‐Agyeman et al. (Thu,) studied this question.