In vitro activity of amoxicillin combined with oral cephalosporins against endocarditis-associated E. faecalis clinical isolates

Key Points

• The aim is to evaluate the effectiveness of amoxicillin combined with cefixime against E. faecalis.
• Conducted in vitro tests using clinical E. faecalis isolates.
• Assessed the synergy between amoxicillin and cefixime.
• Analyzed the results at standard inoculum concentrations.
• Amoxicillin and cefixime combination shows synergy in the majority of E. faecalis strains.
• The results suggest cefixime may enhance treatment effectiveness when used with amoxicillin.