What question did this study set out to answer?

The study aims to induce configurational stability in flexible expanded heterohelicenes and explore their chiroptical properties.

April 15, 2026Open Access

Inducing configurational stability in inherently flexible expanded heterohelicenes and unlocking stimuli-responsive chiroptical switching

Key Points

The study aims to induce configurational stability in flexible expanded heterohelicenes and explore their chiroptical properties.
Synthesis of π-expanded heterohelicenes with different substituents
Investigation of structural flexibility and enantiomerization barriers
Assessment of chiroptical switching characteristics under various stimuli
Configurable stability achieved for certain heterohelicene derivatives
Demonstrated low enantiomerization barriers indicating high flexibility
Successful chiroptical switching observed under specific conditions

Abstract

“π-Expanded” (hetero)helicenes attracted special attention by virtue of their increased helical diameter, enlarged cavity, structural flexibility, and dynamics. However, their structural flexibility results in low enantiomerization barriers (ΔGe‡ <20 kcal·mol−1),...

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Authors

Manisha Pal

Indian Institute of Science Education and Research, Bhopal

Pirudhan Karak

Indian Institute of Science Education and Research, Bhopal

Debranjan Hati

Jawaharlal Nehru Centre for Advanced Scientific Research

Journals

Chemical Science

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Inducing configurational stability in inherently flexible expanded heterohelicenes and unlocking stimuli-responsive chiroptical switching

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Abstract

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