Marine-derived oral nanovesicles from Sargassum fusiforme ameliorate steatohepatitis by activating the HO-1 pathway to inhibit NF-κB signaling and restore small intestinal homeostasis

Key Points

• The research aims to investigate the potential of marine-derived nanovesicles in treating metabolic-associated steatohepatitis (MASH).
• Utilized marine-derived oral nanovesicles from Sargassum fusiforme.
• Evaluated the activation of the HO-1 pathway.
• Analyzed the effects on NF-κB signaling.
• Assessed the restoration of small intestinal homeostasis.
• SF-NVs effectively reduced inflammation associated with steatohepatitis.
• Activation of the HO-1 pathway was observed.
• Significant inhibition of NF-κB signaling occurred.
• Improvements in small intestinal homeostasis were documented.