Study on the Modes of Cell Death in Lung Cancer Epithelial Cells During Acute EBV Infection Using a Co‐Culture Model

Key Points

• The study aims to explore how acute EBV infection affects cell death in lung cancer epithelial cells.
• Utilized a co-culture model to simulate EBV infection.
• Investigated cell death mechanisms including necroptosis, apoptosis, and pyroptosis.
• Analyzed internalized B cells within cell-in-cell structures.
• Acute EBV infection leads to pMLKL-mediated necroptosis in lung cancer cells.
• Minimal involvement of apoptosis and pyroptosis was observed.
• Presence of various death modalities in cell-in-cell structures was noted.