What question did this study set out to answer?

To evaluate the effects of a specialized toothpaste on inflammation and nitric oxide levels in gingivitis.

April 17, 2026Open Access

Betaine‐, xylitol‐, and extra virgin olive oil–based toothpaste modulates inflammation and oral nitric oxide pathway: Clinical trial in gingivitis

Key Points

To evaluate the effects of a specialized toothpaste on inflammation and nitric oxide levels in gingivitis.
Conducted a clinical trial in gingivitis patients
Utilized toothpaste containing betaine, xylitol, and extra virgin olive oil
Measured inflammation and nitric oxide-related markers as outcomes
Toothpaste significantly reduced gum inflammation
Improved markers related to nitric oxide production
Participants experienced better oral health outcomes

Abstract

ClinicalTrials.gov identifier: NCT05463484 PLAIN LANGUAGE SUMMARY: A toothpaste containing extra virgin olive oil, xylitol, and betaine reduced gum inflammation and improved nitric oxide-related markers in patients with gingivitis.

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