What question did this study set out to answer?

The research examines the relationship between chloroquine resistance and susceptibility to antimalarial treatments in Gambian Plasmodium falciparum.

April 18, 2026Open Access

Chloroquine resistance transporter drives divergent multilocus drug resistance genetic backgrounds and susceptibility in Gambian Plasmodium falciparum

Key Points

The research examines the relationship between chloroquine resistance and susceptibility to antimalarial treatments in Gambian Plasmodium falciparum.
Analyzed genetic variations in Plasmodium falciparum samples from The Gambia.
Monitored resistance patterns and sensitivity to antimalarial drugs.
Assessed the presence of pfkelch13 mutations.
Chloroquine resistance is influenced by genetic backgrounds in the parasite.
Lack of pfkelch13 mutations correlates with the effectiveness of artemisinin combination therapies (ACTs).
Reversion to chloroquine sensitivity may compromise ACT efficiency.

Abstract

ACTs remain effective in The Gambia, supported by the absence of pfkelch13 mutations. However, reversion to chloroquine sensitivity tend to result in reduced sensitivity to ACT drugs. These genotype-phenotype dynamics needs continuous monitoring to guide drug interventions towards malaria elimination.

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Cite This Study

Drammeh et al. (Wed,) studied this question.

synapsesocial.com/papers/69e31ec840886becb653e701 https://doi.org/https://doi.org/10.1016/j.jgar.2026.04.003

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