Single-photon emission computed tomography 123I-ioflupane imaging in CSF1R mutation carriers

Key Points

• This research aims to investigate Parkinsonism characteristics in CSF1R mutation carriers using SPECT imaging.
• Conducted imaging using iodine-123 ioflupane SPECT.
• Analyzed results in individuals with CSF1R mutations.
• Evaluated the correlation between SPECT findings and clinical symptoms.
• Normal SPECT results observed in CSF1R mutation carriers.
• Motor deficits attributed to white matter degradation and disrupted connectivity, not nigrostriatal loss.