Clinicians often concurrently tackle critical challenges including emergency hemorrhage, secondary infection, and the elusive tracking of biodegradation of conventional hemostatic agents for complex wounds. Here, we report an intelligent hemostatic sponge (spCS@AIE) by incorporating aggregation‐induced emission (AIE) nanoparticles with short‐wave infrared (SWIR) fluorescence and photodynamic properties into a chitosan matrix through several weak interactions in a self‐assembled manner. This multifunctional platform enables rapid hemostasis, strong antibacterial and anti‐inflammatory activity, and real‐time monitoring of wound healing and sponge degradation through SWIR fluorescence. The synergistic effect of photodynamic properties by AIE nanoparticles and the cationic nature of chitosan also result in efficient antibacterial rates of 98.8 and 91.7% against Escherichia coli ( E. coli ) and methicillin‐resistant Staphylococcus aureus ( MRSA ), respectively. The sponge here also accelerates oral wound healing within 21 days and fully degrades within 11 days. This work advances hemostatic materials by combining therapeutic efficacy with diagnostic capability, offering a comprehensive solution for wound management and bridging the material innovation with clinical practice.
Liu et al. (Thu,) studied this question.