Human hypofunctional NCF1 variant aggravates salivary gland immunopathology in Sjögren’s disease by promoting switched memory B-cell recruitment and long-lived plasma cell differentiation

Key Points

• The aim is to understand how low NCF1 activity influences immunological responses in Sjögren’s disease.
• Analyzed the effects of NCF1 variants on switched memory B-cell recruitment
• Investigated IgG+ plasma cell differentiation in the context of Sjögren’s disease
• Low NCF1 activity significantly increases switched memory B-cell trafficking.
• Increased differentiation of IgG+ plasma cells is associated with NCF1 hypofunction.