In this paper, a new synthetic method for the synthesis of γ-keto sulfones via the reaction of chalcones with sulfonyl hydrazide under thermal and acidic conditions was investigated. This protocol provides easy and direct access to γ-keto sulfones with yields ranging from good to excellent (80–92%), reasonable reaction completion times (40–60 min), and high chemical selectivity. 1 H NMR, 13 C NMR, FT-IR, and mass spectrometry confirmed the structures of the γ-keto sulfone derivatives. Among the advantages of this method were the high yields of the products, shorter reaction times, the absence of side products, and the ease of separating the products from the reaction medium. In this work, we developed a novel method for the synthesis of γ-keto sulfones without the use of radical compounds or radical-generating metal catalysts. In this method, we were able to synthesize γ-keto sulfone compounds from existing sulfonyl hydrazide compounds under acidic and thermal conditions.
Kafshgari et al. (Wed,) studied this question.