ABSTRACT Solid‐state nuclear magnetic resonance (ss‐NMR) is a potent analytical technique for investigating the dynamic, structural, and chemical stability characteristics of complex pharmaceutical compounds. This review presents recent advances in ss‐NMR applications in investigating various drug categories, including hormonal peptides, central nervous system drugs, antibiotics, and macromolecular therapeutics. This review also discuss the mechanism through which ss‐NMR elucidates subtle molecular interactions, degradation pathways, polymorphism, and drug‐excipient compatibility under normal or stressed environments. The study also explores combining ss‐NMR with cutting‐edge methods like cryo‐electron microscopy and computational modeling, enhancing structural resolution, and functional insight. Despite its analytical strength, ss‐NMR remains underutilized in routine pharmaceutical quality control, particularly for early detection of chemical instability. Thus, ss‐NMR is a research subject and a transformative approach in regulatory‐compliant drug stability testing.
Sahu et al. (Wed,) studied this question.