Therapeutic effect and impact of Cyclin D1 and cyclin-dependent protein kinase 4 expression in patients with vulvar lichen simplex chronicus treated using focused ultrasound

Key Points

• This research aims to evaluate the therapeutic effects of focused ultrasound on vulvar lichen simplex chronicus and its impact on cyclin D1 and CDK4 expression.
• Evaluated the clinical symptoms of patients with vulvar lichen simplex chronicus before and after focused ultrasound treatment.
• Analyzed the expression levels of cyclin D1 and CDK4 in lesional tissues pre- and post-treatment.
• Focused ultrasound effectively reduced clinical symptoms of vulvar lichen simplex chronicus.
• The treatment was associated with a decrease in cyclin D1 and CDK4 expression levels.
• Restoration of normal distribution patterns for cyclin D1 and CDK4 was observed in treated tissues.