Lactate‐Induced Liquid–Liquid Phase Separation of HIF ‐1α Drives Myeloid Cell Polarization and Immune Evasion in Colorectal Cancer

Key Points

• The central aim is to explore how lactate affects HIF-1α and contributes to myeloid cell polarization and immune evasion in colorectal cancer.
• Examined the effects of lactate on HIF-1α phase separation
• Investigated myeloid cell responses
• Analyzed immune evasion mechanisms in colorectal cancer
• Lactate induces liquid-liquid phase separation of HIF-1α, promoting myeloid cell polarization.
• Enhanced immune evasion is observed in the presence of lactate.
• Polarized myeloid cells exhibit altered immune responses in cancer.