Alpha-fetoprotein-producing gastric cancer (AFPGC) is a highly malignant subtype of gastric cancer with unique biological characteristics and clinical phenotypes. With the continuous development of molecular biology techniques and diagnostic methods, there has been a deeper understanding of AFPGC in terms of its epidemiological distribution, pathological features, and molecular-level pathogenesis. However, early identification and effective intervention for this type of tumor remain challenging in clinical practice. Current research mainly focuses on discovering potential molecular markers, optimizing diagnostic procedures, and exploring feasible treatment pathways. Despite these efforts, the specific pathogenic mechanism of AFPGC still needs further clarification, and the construction of individualized, multi-modal combined treatment systems also requires further improvement. This article systematically reviews the latest research achievements in the field of AFPGC, aiming to comprehensively sort out the existing knowledge system, provide references for further understanding the complexity of this disease, and promote breakthroughs and innovations in future diagnosis and treatment strategies.
Liu et al. (Mon,) studied this question.