Efficient aqueous solubilization of methylxanthines via complexation with natural polyphenolate salts

Key Points

• This research aims to investigate how polyphenolate salts can enhance the aqueous solubility of methylxanthines like caffeine.
• Examined effects of polyphenolate salts on caffeine solubility
• Analyzed complexation mechanisms
• Compared results to conventional extraction methods.
• Displayed significant increase in caffeine solubility due to π–π stacking-driven complexation
• Showed that polyphenolate salts provide a greener extraction alternative.