Alkylation/Cyclization Reaction of N -Aryl- N -(3-phenylpropioloyl)methacrylamide for the Synthesis of Cyanomethylated and Hydroxymethylated Succinimide Derivatives

Key Points

• This study aims to develop efficient reactions for the synthesis of cyanomethylated and hydroxymethylated succinimide derivatives using N-phenyl-N-(3-arylpropioloyl)methacrylamide.
• Cyanomethylation and hydroxymethylation cyclization reactions were performed using haloacetonitrile and isopropanol as alkylating reagents.
• The approach was tested across a broad substrate scope under mild conditions.
• Radical reaction processes were employed to achieve high yields and configurational selectivity.
• The synthetic strategy produced halogenated and cyanomethylated succinimide derivatives with high yields.
• Atomic economy is extremely high, ensuring all substrate atoms are retained in product structures.
• Configurational selectivity was excellent across the tested substrates.